UV Spectrophotometric method has been developed for simultaneous estimation of Paracetamol (PCM) and Pamabrom (PAM) in bulk drug and in laboratory mixture. This method utilizes 0.1 N NaOH as a solvent and λmax of Paracetamol and Pamabrom selected for analysis was found to be 257 nm and 280 nm respectively. Linearity was observed in the concentration range of 2-12 μg/ml for Paracetamol (r2=0.999) and 5-15 μg/ml for Pamabrom (r2=0.999). The method was validated statistically and by recovery studies. The mean % recovery was 99.63-100.83% and 98.70-101.98% for Paracetamol and Pamabrom respectively. Developed method was applied to laboratory mixture. The results were found to be within acceptance criteria according to ICH guideline. This method was simple, rapid, accurate and sensitive.
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